Meet the new guard: Interleukin blockers
“For the first time ever, the newest biologics can take someone from having psoriasis to no psoriasis. They are completely clear,” says Mark Kauffman, MD, an associate clinical professor of dermatology at Icahn School of Medicine at Mount Sinai in New York City. Given by shot or intravenous (IV) infusion, biologics are reserved for people with moderate to severe psoriasis. In the past, biologic drugs tended to aim their bow and arrow at tumor necrosis factor-alpha, which plays a role in the inflammatory cascade known to cause psoriasis. The newest crop of biologics, however, gets even more specific in their aim, making them that much more effective and safe. They are even effective if someone has tried and failed or stopped responding to older biologics.
Bruce Strober, MD, chair of dermatology at UConn Health and professor of dermatology at UConn School of Medicine, with offices in Farmington and Canton, Conn. agrees. “The most exciting new treatments for psoriasis lately are Tremfya, Cosentyx, Siliq, and Taltz as they clear most patients who receive them and have very few side effects, and no need for blood test monitoring (except for a pre-treatment test for tuberculosis),” he says. Biologics do confer their share of risks namely infections because they work by suppressing your immune system. This new crop is thought to be more “skin-specific” which means there is less broad immunosuppression and thus a lower risk for infections.
Find out the best skin care routine for psoriasis from top dermatologists.
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